Valeria Vargas-Olmedo, 11, from Crestline, California, United States, received her stem cell donation from her father. It was the first stem cell transplant at Loma Linda’s Children Hospital. Photo: Loma Linda University News

Doctors at Loma Linda University Children’s Hospital recently conducted the institution’s first stem cell transplant in a sickle cell disease patient, effectively curing her of the inherited blood disease. The successful procedure offers hope and accessible treatment to those suffering from the disease in the area close to the Loma Linda, California, United States, Seventh-day Adventist institution and surrounding regions.

Children’s Hospital doctors had worked for nearly a year to build a program focused on helping hematology patients, specifically those with hemophilia and sickle cell disease.

Akshat Jain, director of pediatric hematology-oncology at Children’s Hospital, said he is pleased with the outcome of the transplant and what it means for future patients suffering from sickle cell disease.

“We created a successful program, so children and their families suffering from this disease don’t need to look elsewhere for treatment — it’s available to them right here in the area,” Jain said.

The procedure was also Children’s Hospital’s first haploidentical transplant, meaning the stem cells donated — by the patient’s father — were only half a genomic match to the patient’s own stem cells and were modified by the transplant team to replace the unhealthy blood-forming cells.

The patient, 11-year-old Valeria Vargas-Olmedo, had lived with sickle cell disease since birth. Her family began seeking treatment last year after she became incapacitated, unable to continue daily activities such as attending school, getting into a car, or even walking. Doctors said she had debilitating chronic pain, bone loss, and bone necrosis.

“She is now disease free and can go back out into the world to do what an 11-year-old should be doing,” Jain said.

Sickle cell disease causes a shortage of red blood cells and thus an oxygen deficiency in a person’s body. This can cause chronic pain and other serious complications, such as infection, acute chest syndrome, and stroke. Without oxygen, any internal organ has a high likelihood of dying off.

Jain said the disease is generally found in populations like those who live in the region around the hospital, especially among Hispanic and African American populations.

Jain said he and his team treat approximately 250 to 300 sickle cell patients in Children’s Hospital’s comprehensive sickle cell program — more patients than in some of the largest programs on the U.S. west coast.

Clara Olmedo, Valeria’s mother, said, “Firstly, we want to thank God. We also want to thank Dr. Jain and his entire transplant team. Finally, thanks to Valeria’s father — he did everything he could in order to save her life and give her health through being a donor. My daughter is much more animated now — she’s begun walking, she’s eating and gaining weight, and she’s happy. Little by little she is living a normal life like before.”

The Vargas-Olmedo family encouraged other families who are struggling with sickle cell disease. “For the parents who see the news of this transplant and deal with this sickness, I hope they are encouraged and know that Children’s Hospital is a great hospital,” Clara Olmedo said. “There are many good doctors, professionals, and excellent nurses. I encourage them to ask more questions about this procedure and our experience. They’ve helped us tremendously, and we have our trust in them.”

This story was originally posted on the Loma Linda University Health news site.

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